Cisplatin nrf2

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August undefined, 2024

WebMar 15, 2014 · Cisplatin resistance is a major problem affecting ovarian carcinoma treatment. NF-E2-related factor 2 (Nrf2), a nuclear transcription factor, plays an … WebOur results indicated that similar to NRF2, cisplatin-induced reduction of MDM2 was also significantly blocked by ω-3 PUFAs. Inhibition of NRF2 activity abolished ω-3 PUFAs-induced expression of MDM2, and stimulated p53 expression in BM cells (Fig. 8). Together, these results indicate that NRF2 is a positive transcriptional regulator of MDM2 ...

CCT4 knockdown enhances the sensitivity of cisplatin by …

WebResults: Metformin was observed to synergistically augment cisplatin-induced cytotoxicity by strongly inhibiting the level of Nrf2, thereby weakening the antioxidant system and detoxification ability of Nrf2 and enhancing ROS-mediated apoptosis in NSCLC. The synergistic antitumor effect of combination therapy is blocked by treatment with the ... WebAug 14, 2010 · Key findings: Cisplatin caused a significant decrease in the expression nuclear levels of NF-E2-related factor-2 (Nrf2), heme oxygenase-1(HO-1), and an increase in the levels of nuclear factor-kappa B (NF-kappaB p65) and 4-hydroxynonenal (HNE) an oxidative stress marker. EGCG supplementation significantly improved the changes … city data cross city florida

IJMS Free Full-Text Multifaceted Mechanisms of Cisplatin …

WebFeb 2, 2024 · Recently, a large number of articles have found that agents including edaravone and epigallocatechin-3-gallate (EGCG) prevented the development of … WebMay 19, 2024 · Activation of MT1/MT2 to Protect Testes and Leydig Cells against Cisplatin-Induced Oxidative Stress through the SIRT1/Nrf2 Signaling Pathway Activation of MT1/MT2 to Protect Testes and Leydig Cells against Cisplatin-Induced Oxidative Stress through the SIRT1/Nrf2 Signaling Pathway Authors WebDec 1, 2024 · Cisplatin is a chemotherapeutic drug that suppresses tumour's growth. • Cisplatin’s effectiveness is limited as it causes liver toxicity. • Various natural antioxidants protect against cisplatin-induced hepatotoxicity. • Hepatoprotective mechanisms are antioxidant, anti-inflammatory, and anti-apoptosis. dictionary reckon

Dissecting the Crosstalk Between Nrf2 and NF-κB …

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WebFeb 6, 2024 · Cordyceps cicadae Mycelia Ameliorate Cisplatin-Induced Acute Kidney Injury by Suppressing the TLR4/NF- κ B/MAPK and Activating the HO-1/Nrf2 and Sirt-1/AMPK Pathways in Mice Oxid Med Cell Longev. 2024 Feb 6;2024:7912763. doi: 10.1155/2024/7912763. eCollection 2024. Authors WebJun 7, 2024 · Importantly, restoring Nrf2 signaling overturned ATF3-mediated ferroptosis and cisplatin resistance. Conclusion: ATF3 may sensitize GC cells to cisplatin by induction of ferroptosis via blocking Nrf2/Keap1/xCT signaling, supporting a promising therapeutic approach for overcoming chemoresistance in GC. dictionary recombineWebApr 1, 2024 · Alginate Oligosaccharide Alleviated Cisplatin-Induced Kidney Oxidative Stress via Lactobacillus Genus-FAHFAs-Nrf2 Axis in Mice Alginate Oligosaccharide Alleviated Cisplatin-Induced Kidney Oxidative Stress via Lactobacillus Genus-FAHFAs-Nrf2 Axis in Mice Front Immunol. 2024 Apr 1;13:857242. doi: 10.3389/fimmu.2024.857242. … city data for kerrville tx

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Cisplatin nrf2

The role of natural antioxidants in cisplatin-induced …

WebJan 15, 2024 · Cisplatin-induced loss of fascin2, an actin bundling protein, was observed in cells with a stable knockdown of α (E)-catenin (C2 cells), as well as in aging (24 mon), … WebMay 1, 2024 · This was associated with inhibition of Nrf2 defense pathway. Moreover, cisplatin increased the expression of pro-inflammatory mediators in the kidney tissues. …

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WebThere is accumulating evidence that breast cancer 1 (BRCA1), sirtuin 1 (SIRT1), and epidermal growth factor receptor (EGFR) help to modulate cisplatin cytotoxicity. The role of dynamic crosstalk amon WebTherapeutic efficacy of cisplatin-based treatment of late stage urothelial carcinoma (UC) is limited by chemoresistance. To elucidate underlying mechanisms and to develop new approaches for overcoming resistance, we generated long-term cisplatin treated (LTT) UC cell lines, characterised their cisplatin response, and determined the expression of …

WebMay 1, 2024 · Nrf2 activation can protect cells against side effects of chemotherapeutic agents. • Cisplatin (CP) inhibits cancer progresion via inducing DNA damage and … WebAbstract: ObjectiveTo investigate the effect of cisplatin on the protein expression and nuclear translocation of Nrf2, and on the changes of autophagy and apoptosis in HeLa …

WebSep 15, 2024 · Cisplatin Injection (cisplatin injection (cisplatin (cisplatin injection) injection) ) is a sterile aqueous solution, available in 50, 100 and 200 mL multiple dose … WebCisplatin is a chemotherapy medication used to treat a wide range of cancers. A common side effect of cisplatin is myelosuppression. Research suggests that oxidative damages are strongly and consistently related to myelosuppression during cisplatin treatment. ω-3 polyunsaturated fatty acids (PUFAs) can enhance the antioxidant capacity of cells.

WebInterestingly, CCT4 knockdown enhanced the sensitivity of KYSE150 cells to DDP by regulating AMPK/AKT/Nrf2 signaling pathway and inhibiting glycolysis ability. Taken together, our results indicate that targeting CCT4 may be a therapeutic target in ESCC patients, which provides a theoretical basis to enhance the sensitivity of DDP in ESCC.

WebNov 11, 2024 · Farrerol Ameliorated Cisplatin-Induced Chronic Kidney Disease Through Mitophagy Induction via Nrf2/PINK1 Pathway Previously, Our study has showed that farrerol can activate Nrf2 and ameliorate cisplatin-induced acute kidney injury (AKI). Mitophagy reportedly can prevent diabetic nephropathy, cisplatin-induced AKI and other related … city data boise idahoWebDec 26, 2024 · We examined the preventive effect of α-lipoic acid (LA) on cisplatin-induced toxicity via its antioxidant effects on in vitro and ex vivo culture systems. To elucidate the mechanism of the antioxidant activity of LA, NRF2 was inhibited using NRF2 siRNA, and the change in antioxidant activity of LA was characterized. dictionary recognitionWebJun 7, 2024 · Cisplatin (DDP)-based chemotherapy is deemed as a common first-line treatment for cancer patients including GC. Nevertheless, GC patients with advanced disease usually acquire resistance to chemotherapy, resulting in a somber prognosis with a median overall survival of 8–11 months [5]. dictionary reconcileWebDec 18, 2016 · Nrf2 inhibition attenuates artesunate resistance in cisplatin-resistance HNC cells. Artesunate (Arts) selectively kills HNCs but not normal cells viathe induction of iron … dictionary reconnoiterWebApr 1, 2024 · Alginate oligosaccharide is the depolymerized product of alginate, a natural extract of brown algae, which is associated with beneficial health effects. Here, we aimed to investigate the mechanism via which alginate oligosaccharides improve kidney oxidative damage and liver inflammation induced by cisplatin chemotherapy via the gut … dictionary recordingWebSep 1, 2024 · Cisplatin for injection is a cytotoxic drug. Follow applicable special handling and disposable procedures. 1 Reconstitution Reconstitute 50 mg vials with 50 mL of Sterile Water for Injection, USP. Each mL of the resulting solution will contain 1 mg of Cisplatin for injection. Reconstitution results in a clear or colorless to slight yellow solution. dictionary reckoningWebNov 11, 2024 · These data indicated that farrerol effectively inhibited cisplatin-induced inflammation and renal fibrosis by activating Nrf2 and PINK1/Parkin-mediated mitophagy, which provides a potential novel therapeutic target for CKD. Keywords: chronic kidney disease, mitophagy, Nrf2, PINK1, acute kidney injury Go to: Introduction dictionary recklessness