Dlgh1
WebRecent reports also indicate that DLGH1 may be a critical mediator of signals triggered by the antigen receptor complex in T lymphocytes by functioning as a scaffold coordinating the activities of T-cell receptor (TCR) signaling proteins at the immune synapse. WebSynonym(s): Anti-DKFZp686N19164, Anti-FLJ20562, Anti-KIAA0861, Anti-KOX28, Anti-zinc finger protein 30
Dlgh1
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WebIn the mammalian embryo, DLGH1 is essential for normal urogenital morphogenesis and the development of skeletal and epithelial structures. Recent reports also indicate that … WebDlgh1 contains no transmembrane domain or putative sites for lipid modification that would allow it to associate with the plasma membrane or the lipid raft compartment (28). Figure 2. Dlgh1 specifically associates with the Lck SH3 domain, and this interaction is required for Dlgh1 association with detergent-
WebDec 24, 2006 · A Dlgh1 mutant incapable of binding p38 failed to activate NFAT. Along with reports that the CARMA1 MAGUK scaffold protein coordinates activation of Jnk and NF-κB but not of p38 or NFAT, our ... WebThe arrow in D points to a dilated ureter and hydronephrotic kidney. (E) Unilateral renal agenesis in a Dlgh1 / embryo from a different litter; arrow in E points to the uterus. (F and G) H&E ...
WebMay 1, 2007 · Abnormal urogenital organs in prenatal Dlgh1-/-mice at E18.5. (A,D-F) Urinary organs of male Dlgh1 +/+ (A), and male (D) or female (E,F) Dlgh1-/-mice. (D) … WebFeb 7, 2005 · Dlgh1, the mouse homologue of the human hDlg and rat SAP97, is a member of the membrane-associated guanylate kinase protein family (MAGUK). MAGUKs are …
WebApr 1, 2012 · DLGH1, a mammalian homologue of the Drosophila tumour suppressor Discs large 1, is expressed in all the different types of epithelia present in the human uterine …
WebJun 26, 2024 · These data suggest that regardless of their origin, Dlgh1 is essential for optimal Treg function by scaffolding two critical signaling … greenhouse pans for shelvesWebDec 24, 2006 · Dlgh1 contains multiple protein-interaction domains and therefore identification of Dlgh1-interacting proteins in T cells is essential … greenhouse paraffin heater wicksWebDMD is a lethal genetic disease of childhood, caused by mutations in DMD, which encodes the dystrophin protein. Without functional dystrophin, defects in sarcolemma stabilization lead to progressive muscle damage, while inherent stem cell … fly box dubbingWebJun 30, 2010 · The Drosophila 'discs large' tumor suppressor protein, Dlg, is the prototype of a family of proteins termed MAGUKs (membrane-associated guanylate kinase … fly box easyjetWebDec 26, 2006 · Discs-large homolog 1 (DLGH1) is a mouse ortholog of the Drosophila discs-large (DLG) tumor suppressor protein, a founding member of the PDZ and MAGUK protein families. DLG proteins play important roles in regulating cell proliferation, epithelial cell polarity, and synapse formation and function. flybox facebookWebGene: Dlg1 MGI:107231 Not currently registered for phenotyping at IMPC Phenotyping is currently not planned for a knockout strain of this gene. Gene Summary Name: discs large MAGUK scaffold protein 1 Synonyms: B130052P05Rik, SAP97, Dlgh1 Order Alleles IMPC Data Collections No Body Weight Data No Embryo Imaging Data No Viability Data fly box engine monitorWebFeb 7, 2005 · We propose that Dlgh1 coordinates TCR/CD28-induced actin-driven T cell synapse assembly, signal transduction, and effector function. These findings highlight … greenhouse partnership